An Adaptive Poly-Parental Recombination Strategy

نویسندگان

  • Jim Smith
  • Terence C. Fogarty
چکیده

A genetic recombination framework is presented within which both the unit of inheritance of genetic material from a parent, and the number of parents involved in the creation of a new individual are potentially learnt through the evolution of competing subpopulations representing different strategies. At the heart of the framework is a recombination mechanism whereby a newly created member of the population may be the result of the conjunction of genetic material from any number of parents, from a low of one up to a maximum limited by the number of genes in the individual chromosome. This is achieved by the use of a representation with genotypically encoded “links” between adjacent genes, which are respected during recombination. Initially the system contains subpopulations with differing degrees of linkage, and these link bits are subject to mutation. Thus the framework encompasses a variety of strategies from population based random mutation hill-climbing through to the simultaneous parallel optimisation of each locus individually cf. Syswerda’s Simulated Crossover, and the competition between subpopulations representing these strategies allows the amount and type of recombination to adapt as the search progresses. The performance of the operator is demonstrated by comparisons with other common recombination strategies over a range of function optimisation problems designed to illustrate a variety of degrees of epistasis and deception. The flexibility of the operator in terms of various parameter settings is investigated, and an analysis is given of the different strategies adopted by the framework to solve different classes of problems.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of adaptive responses to cisplatin in normal and mutant cell lines with mutations in recombination repair pathways.

Cell lines mutant in specific DNA repair pathways were used to determine if these pathways are involved in adaptive responses. For these studies, the effect of deficiencies in homologous recombination repair (HR) were studied in the parental AA8 and mutant (irs)ISF cell line pair and for deficiencies in the nonhomologous endjoining (NHEJ) pathway in the mouse MEF parental and Ku80 mutant cell l...

متن کامل

An Examination of the Relationship between Hotspots and Recombination Associated with Chromosome 21 Nondisjunction

Trisomy 21, resulting in Down Syndrome (DS), is the most common autosomal trisomy among live-born infants and is caused mainly by nondisjunction of chromosome 21 within oocytes. Risk factors for nondisjunction depend on the parental origin and type of meiotic error. For errors in the oocyte, increased maternal age and altered patterns of recombination are highly associated with nondisjunction. ...

متن کامل

Reproductive Isolation of Hybrid Populations Driven by Genetic Incompatibilities

Despite its role in homogenizing populations, hybridization has also been proposed as a means to generate new species. The conceptual basis for this idea is that hybridization can result in novel phenotypes through recombination between the parental genomes, allowing a hybrid population to occupy ecological niches unavailable to parental species. Here we present an alternative model of the evol...

متن کامل

Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways.

Many established cancer therapies involve DNA-damaging chemotherapy or radiotherapy. Gain of DNA repair capacity of the tumor represents a common mechanism used by cancer cells to survive DNA-damaging therapy. Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is activated by DNA damage and plays a critical role in base excision repair. Inhibition of PARP represents an attractive a...

متن کامل

O 20: The Role of Neuroinflammation in Epilepsy: A New Target for Treatment

Despite progress in pharmacological and surgical treatments of epilepsy, little is known about the processes that a healthy brain is rendered epileptic after seizure occurrence. Growing evidence supports the involvement of inflammatory processes, both the adaptive immunity and systemic inflammatory response, in induction of individual seizures as well as in the epileptogenesis. Clinical and exp...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1995